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Postdoctoral Research Fellow

Company: FDA
Location: Pine Bluff
Posted on: September 13, 2019

Job Description:

Description A research opportunity is currently available in the Division of Biochemical Toxicology, National Center for Toxicological Research (NCTR) of the U.S. Food and Drug Administration (FDA) Jefferson Laboratories Campus located in Jefferson, Arkansas. Research efforts will include participation in multi-disciplinary efforts in a nationally recognized training program in support of the FDA's mission. The primary objective of this project is to construct an integrated computational tool, which consists of databases, referenced literatures, and a multi-pathway physiologically based pharmacokinetic (PBPK) model for tobacco components, to assist FDA Center for Tobacco Products make science-based regulatory decisions for reducing the abuse liability and adverse public health impact from tobacco products in humans. The participant will learn skills in developing PBPK models for nicotine and its major metabolites, cotinine and 3-OH cotinine, administered in humans via different routes of exposure ranging from intravenous and oral to more complex exposure scenarios resulting from combusted tobacco smoke or vaping (inhalation) and smokeless tobacco products (buccal uptake). During the project, the participant will be encouraged to present research results at internal and external meetings and publish the findings in peer-reviewed journals. Anticipated appointment start date: October 1, 2019.Applications will be reviewed on a rolling basis. This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of--FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at--FDA in the Jefferson, Arkansas, area. Participants do not become employees of--FDA, DOE or the program administrator, and there are no employment-related benefits. Completion of a successful background investigation by the Office of Personnel Management is required for an applicant to be on-boarded at FDA. OPM can complete a background investigation only for individuals, including non-US Citizens, who have resided in the US for a total of three of the past five years. Qualifications: The qualified candidate should have received a doctoral degree in one of the relevant fields (biological sciences, toxicology, pharmacometrics, computational biology, mathematics, statistics, chemical/biomedical engineering or related fields), or be currently pursuing the degree and will reach completion by October 1, 2019. Degree must have been received within five years of the appointment start date. Preferred skills: Hands-on experience with computational modeling and simulation as well as knowledge of pharmacokinetics and toxicological principles.Experience with software to characterize the deposition and clearance of aerosols in the respiratory tracts for inhalation exposure, such as Multiple Path Particle Dosimetry Model (MPPD), is a strong plus.Demonstrated written and oral communication skills.Must have the interest and desire to learn the development and application of computational modeling for risk assessment. How To Apply If you are interested, please send your current resume/CV to Drs. Jeffrey Fisher (Jeffrey. ) or Darshan Mehta ()

Keywords: FDA, Pine Bluff , Postdoctoral Research Fellow, Other , Pine Bluff, Arkansas

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